Secretomes is a regenerative medicine product expressed by cells and secreted into the extracellular space. They consist of sets of proteins, micro-RNAs, exosomes, and metabolites. Dr. Keith March discovered the potential therapeutic activity of adult stem cell-derived secretomes, which were initially called “Paracrine Factors”, first published in 2003.

The first generation of secretomes were derived from individual patients and used for multiple indications. Theratome has developedsecond generation secretomes, which are optimized by specific stimulation protocols and further refined by removing components that are not desired. For example, a dry eye product (KM102) is a secretome from which angiogenic and neurogenic properties are selectively deleted/diminished and anti-inflammatory components are optimized.