Our Science

About Us
Mission
Leadership
Management Team
Board of Directors
Our Science
Publications
Commercial Opportunities
Investors
News
Events and Presentations
Contact Us

Publications

While Dr. March was the secretome/exosome pioneer with his early publications in 2003 and 2004, the number of publications in this field grew from 282 papers in 2010 to a record 11,968 in 2021.

Globally, there are more than 200 clinical trials focusing on secretome-exosome clinical trials. The majority of these trials are focused on therapeutics but others are related to diagnostic tests.

Theratome Bio management believes that they are the only secretome/exosome company with a product under development that is deemed a medical device (organ preservation).

  1. Rehman J, Li J, Orschell CM, March KL.  Peripheral Blood “Endothelial Progenitor Cells” are Derived from Monocyte/Macrophages and Secrete Angiogenic Growth Factors.  Circulation.  2003 March 4; 107(8):1164-1169.
  2. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm CJ, Bovenkerk JE, Pell C, Johnstone BH, Considine RV, March KL. The Secretion of Angiogenic and Anti-Apoptotic Factors by Human Adipose Stromal Cells. Circulation.   2004 Mar 16; 109(10):1292-98. PMID: 14993122.

Amyotrophic Lateral Sclerosis (ALS):

  1.  Fontanilla C, Gu H, Zhu T, Johnstone BH, March KL, Pascuzzi R, Farlow M. Adipose-derived Stem Cell Conditioned Media Extends Survival of a Mouse Model of Amyotrophic Lateral Sclerosis. Sci Rep. 2015 Nov 20;5:16953. PMID: 26586020.
  2. Walker CL, Meadows RM, Merfeld-Clauss S, Du Y, March KL, Jones KJ. Adipose-derived stem cell conditioned medium impacts asymptomatic peripheral neuromuscular denervation in the mutant superoxide dismutase (G93A) transgenic mouse model of amyotrophic lateral sclerosis. Restor Neurol Neurosci. 2018 Sep; 36(5):621–7. PMID: 30010155.

Acute Respiratory Distress Syndrome (ARDS):

  1.  Lu H, Poirier C, Cook T, Traktuev DO, Merfeld-Clauss S, Lease B, Petrache I, March KL, Bogatcheva NV. Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis. J Transl Med. 2015 Feb 21;13:67. PMID: 25889857.
  2.  Lu H, Merfeld-Clauss S, Jawed Y, March KL, Coleman ME, Bogatcheva NV. Distinct factors secreted by adipose stromal cells protect the endothelium from barrier dysfunction and apoptosis. Front Cell Dev Biol. 2020 Sep;8:584653.ARDS due to virus:
  3. Bogatcheva,N.V., Coleman,M.E. Concentrated Secretome of Adipose Stromal Cells Limits Influenza A Virus-Induced Lung Injury in Mice. Cells2021, 10, 720-738. https://doi.org/10.3390/ cells1004072

Dry Eye Disease (DED)

  1. Li SF, Han Y, Wang F, Su Y. Progress in exosomes and their potential use in ocular diseases. Int J Ophthalmol. 2020 Sep 18;13(9):1493-1498. doi: 10.18240/ijo.2020.09.23. PMID: 32953591; PMCID: PMC7459212.
  2. Mazet R, Yaméogo JBG, Wouessidjewe D, Choisnard L, Gèze A. Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation. Pharmaceutics. 2020 Jun 19;12(6):570. doi: 10.3390/pharmaceutics12060570. PMID: 32575411; PMCID: PMC7356360.
  3. Mazet R, Yaméogo JBG, Wouessidjewe D, Choisnard L, Gèze A. Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation. Pharmaceutics. 2020 Jun 19;12(6):570. doi: 10.3390/pharmaceutics12060570. PMID: 32575411; PMCID: PMC7356360.
  4. Lee, YC., Sun, LY. & Zhang, JR. Protective effects of low-molecular-weight components of adipose stem cell-derived conditioned medium on dry eye syndrome in mice. Sci Rep11, 21874 (2021). https://doi.org/10.1038/s41598-021-01503-z
  5. Li SF, Han Y, Wang F, Su Y. Progress in exosomes and their potential use in ocular diseases. Int J Ophthalmol. 2020 Sep 18;13(9):1493-1498. doi: 10.18240/ijo.2020.09.23. PMID: 32953591; PMCID: PMC7459212.
  6. Michael S. Cooper, OD, Matt Geller, OD (2024, Feb 26). The 2024 Dry Eye Report. Eyes On Eyecare. https://eyesoneyecare.com/resources/2024-dry-eye-report/
  7. Yu, C., Chen, P., Xu, J. et al.hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye. Sci Rep 10, 14521 (2020). https://doi.org/10.1038/s41598-020-71337-8
  8. Nancy LeBron (Published 2022, Aug 15. Dry Eye Facts and Statistics: What You Need to Know. Retrieved March 10, 2024 from https://www.verywellhealth.com/dry-eye-syndrome-facts-6188248
  9. Weiner G. Dry eye is a complex condition with multiple underlying factors and myriad potential diagnostic approaches and treatment. Eyenet Magazine. Retrieved March 11, 2024 from com/ck/a?!&&p=c14025a551e95b22JmltdHM9MTcxMDExNTIwMCZpZ3VpZD0yZGM0YWFkZi1kY2JlLTY0NzgtMjU5Yy1iOWFkZGQ5YjY1ODQmaW5zaWQ9NTIxNA&ptn=3&ver=2&hsh=3&fclid=2dc4aadf-dcbe-6478-259c-b9addd9b6584&psq=dry+eye+is+a+complex+condition+with+multiple+underlying+factors+and+myriad&u=a1aHR0cHM6Ly93d3cuYWFvLm9yZy9Bc3NldHMvMzg2ZjFmY2QtY2MwNC00NjA4LTkyMGQtMGU0ODZlMjM5NDIwLzYzNjY3Nzg0MjQ2NTYzMDAwMC9hdWd1c3QtMjAxOC1mZWF0dXJlLXBkZg&ntb=1
  10. Barnes C. Keratoconjunctivitis Sicca (KCS) or Dry Eye in Dogs. VCA Animal Hospitals. Retrieved on March 10, 2024 from https://www.Keratoconjunctivitis Sicca (KCS) or Dry Eye in Dogs | VCA | VCA Animal Hospitals (vcahospitals.com)
  11. Leonard, CY. Dry Eye: Artificial Intelligence Update. Published 10 June 2023. Review of Opthalmology. Retrieved on March 11, 2024 from https://www.Dry Eye: Artificial Intelligence Update (reviewofophthalmology.com)

Kidney Failure:

  1. Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury. M. Mahbub Ullah, Jason A. Collett, Jacob C. Monroe, Dmitry Traktuev, Michael Coleman, Keith L. March, David P. Basile; in review.
  2. Reference: United States Renal Data System. 2020 USRDS annual data report: Epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2020. Available at: https://adr.usrds.org/2020/end-stage-renal-disease/1- incidence-prevalence-patients-year
  3. Silver SA, Chertow GM. The Economic Consequences of Acute Kidney Injury. Nephron. 2017;137(4):297- 301. doi: 10.1159/000475607. Epub 2017 Jun 9. PMID: 28595193; PMCID:PMC5743773.

Heart (organ) Transplant Preservation:

  1. Organ donation statistics. (n.d.). https://www.organdonor.gov/learn/organ-donation-statistics
  2. Ellis BW, Traktuev DO, Merfeld-Clauss S, Can UI, Wang M, Bergeron R, Zorlutuna P, March KL. Adipose stem cell secretome markedly improves rodent heart and human-induced pluripotent stem cell-derived cardiomyocyte recovery from cardioplegic transport solution exposure. Stem Cells 2021 Feb;39(2):170–82.
  3. Scott SR, March KL, Wang IW, Singh K, Liu J, Turrentine M, Sen CK, Wang M. Bone marrow- or adipose-mesenchymal stromal cell secretome preserves myocardial transcriptome profile and ameliorates cardiac damage following ex vivo cold storage. J Mol Cell Cardiol. 2022 Mar;164:1–12. doi: 10.1016/j.yjmcc.2021.11.002
  4. Wang M, Yan L, Li Q, Yang Y, Turrentine M, March KL, Wang IW. Mesenchymal stem cell secretions improve donor heart function following ex-vivo cold storage. J Thorac Cardiovasc Surg. 2022 Apr; 163(4):e277–e292. doi: 10.1016/j.jtcvs.2020.08.095

Acute Pancreatitis

  1. Roch AM, Maatman TK, Cook TG, Wu HH, Merfeld-Clauss S, Traktuev DO, March KL, Zyromski NJ. Therapeutic use of adipose-derived stromal cells in a murine model of acute pancreatitis. J Gastrointest Surg. 2020 Jan;24(1):67–75. PMID: 31745900
  2. Reference: Peery AF, Crockett SD, Barritt AS, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149(7):1731-1741.e3. doi:10.1053/j.gastro.2015.08.045 

Stress Urinary Incontinence:

  1. Stem Cell Secretome Accelerates Recovery from Stress Urinary Incontinence Brian Balog *, Kangli Deng,
    Mei Kuang, Anna Rietsch, Katelyn Woolley, Cleveland, OH, Martin Cramer, Michael Coleman, Journal of Urology. 2021 206, 3S, e932
  2. Anger JT, Saigal CS, Litwin MS. The prevalence of urinary incontinence among community dwelling adult women: Results from the National Institutes of Health

Cerebrovascular Accident (CVA, Stroke):

  1. Roche B, New Ways to Act F.A.S.T. Initiatives to Speed Up Diagnosis of Stroke. https://bettydroche.wordpress.com/2017/11/20/new-ways-to-act-f-a-s-t-initiatives-to-speed-up- diagnosis-of-stroke/
  2. Wei X, Du Z, Zhao L, Feng D, Wei G, He Y, Tan J, Lee WH, Hampel H, Dodel R, Johnstone BH, March KL, Farlow MR, Du Y. IFATS collection: The conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells. 2009 Feb;27(2):478-88. PMID: 19023032.
  3. Zhao L, Wei X, Ma Z, Feng D, Tu P, Johnstone BH, March KL, Du Y. Adipose stromal cell-conditioned medium protected glutamate-induced CGNs neuronal death by BDNF. Neurosci Lett. 2009 Mar 20;452(3):238-40. PMID: 19348731.
  4. Wei X, Zhao L, Zhong J, Gu H, Feng D, Johnstone BH, March KL, Farlow MR, Du Y. Adipose stromal cell- secreted neuroprotective media against neuronal apoptosis. Neurosci Lett. 2009 Oct 2;462(1):76-9. PMID: 19549558.

Prevention of Limb Amputation:

  1. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm CJ, Bovenkerk JE, Pell C, Johnstone BH, Considine RV, March KL. The Secretion of Angiogenic and Anti-Apoptotic Factors by Human Adipose Stromal Cells. Circulation. 2004 Mar 16; 109(10):1292-98. PMID: 14993122.
  2. Procházka V1, Jurčíková J, Laššák O, Vítková K, Pavliska L, Porubová L, Buszman PP, Krauze A, Fernandez C, Jalůvka F, Špačková I, Lochman I, Jana D, Merfeld-Clauss S, March KL, Traktuev DO, Johnstone BH. Therapeutic Potential of Adipose-Derived Therapeutic Factor Concentrate for Treating Critical Limb Ischemia. Cell Transplant. 25(9), pp. 1623–1633. 
  3. Goodney PP, Travis LL, Nallamothu BK, et al. Variation in the use of lower extremity vascular procedures for critical limb ischemia. Circ Cardiovasc Qual Outcomes. 2012;5(1):94-102. doi:10.1161/CIRCOUTCOMES.111.963811
Scroll to Top